Some "water pills" that can deplete potassium include chlorothiazide (Diuril), chlorthalidone (Thalitone), furosemide (Lasix), hydrochlorothiazide (HCTZ, HydroDiuril, Microzide), and others. Calif Med 1962;96(6):412-413. Taking some antibiotics called tetracycline antibiotics along with oleander might increase the chance of side effects from oleander. Mekhail, T., Kaur, H., Ganapathi, R., Budd, G. T., Elson, P., and Bukowski, R. M. Phase 1 trial of Anvirzel in patients with refractory solid tumors. Clinical studies]. Blum, L. M. and Rieders, F. Oleandrin distribution in a fatality from rectal and oral Nerium oleander extract administration. Bourgeois, B., Incagnoli, P., Hanna, J., and Tirard, V. [Nerium oleander self poisoning treated with digoxin-specific antibodies]. Management of acute yellow oleander poisoning. Two different mechanisms of production]. View abstract. J Indian Med Assoc. Terms of Use. Ther Drug Monit. View abstract. View abstract. 1996;94(4):149-150. View abstract. Cancer Res. de Silva, H. A., Fonseka, M. M., Pathmeswaran, A., Alahakone, D. G., Ratnatilake, G. A., Gunatilake, S. B., Ranasinha, C. D., Lalloo, D. G., Aronson, J. K., and de Silva, H. J. Multiple-dose activated charcoal for treatment of yellow oleander poisoning: a single-blind, randomised, placebo-controlled trial. Researchers have suggested that it could be useful to treat cancer because of the way it affects cells, and that it could enhance the effects of other … Kaojarern, S., Sukhupunyarak, S., and Mokkhavesa, C. Oleander Yee tho poisoning. Psychosomatics 2013;54:379-81. Water pills (Diuretic drugs) interacts with OLEANDER. Uncontrolled Blood Sugar: How Dangerous Is It? J Med Assoc.Thai. 1-26-1993;82(4):121-122. Wang, X., Plomley, J. Anal.Chem 8-1-2000;72(15):3547-3552. Haynes BE, Bessen HA, Wightman WD. de Silva, H. A., Fonseka, M. M., Pathmeswaran, A., Alahakone, D. G., Ratnatilake, G. A., Gunatilake, S. B., Ranasinha, C. D., Lalloo, D. G., Aronson, J. K., and de Silva, H. J. Multiple-dose activated charcoal for treatment of yellow oleander poisoning: a single-blind, randomised, placebo-controlled trial. View abstract. View abstract. Arriola, Martinez P., Montero, Aparicio E., Martinez, Odriozola P., and Miguel, de la, V. [Toxicity due to oleander (Nerium oleander) ingestion]. Interference of oleandrin and oleandrigenin in digitoxin immunoassays: minimal cross reactivity with a new monoclonal chemiluminescent assay and high cross reactivity with the fluorescence polarization assay. J Virol 1995;69:4656-7. Furbee B, Wermuth M. Life-threatening plant poisoning. Roberts, D. M., Southcott, E., Potter, J. M., Roberts, M. S., Eddleston, M., and Buckley, N. A. Pharmacokinetics of digoxin cross-reacting substances in patients with acute yellow Oleander (Thevetia peruviana) poisoning, including the effect of activated charcoal. View abstract. A case report. There isn't enough information to know whether or not it is safe to apply oleander to the skin. Lancet 2000;355:967-72. 7-15-2000;60(14):3807-3812. Bavunoglu I, Balta M, Türkmen Z. Oleander Poisoning as an example of self-medication attempt. A., Madden, T., Vijjeswarapu, M., and Newman, R. A. Inhibition of export of fibroblast growth factor-2 (FGF-2) from the prostate cancer cell lines PC3 and DU145 by anvirzel and its cardiac glycoside component, oleandrin(1). View abstract. ©1996-2020 MedicineNet, Inc. All rights reserved. J Anal.Toxicol. Oleander toxicity: an examination of human and animal toxic exposures. 2005;24(6):640-642. View abstract. View abstract. Oleander contains chemicals called glycosides, which can affect the heart. Tyler's Honest Herbal, 4th ed., Binghamton, NY: Haworth Herbal Press, 1999. Safadi, R., Levy, I., Amitai, Y., and Caraco, Y. Camphausen, C., Haas, N. A., and Mattke, A. C. Successful treatment of oleander intoxication (cardiac glycosides) with digoxin-specific Fab antibody fragments in a 7-year-old child: case report and review of literature. J Indian Med Assoc. View abstract. Azzalini E, Bernini M, Vezzoli S, Antonietti A, Verzeletti A. View abstract. 11-18-2006;127(19):759. Do not take oleander if you are taking digoxin (Lanoxin) without talking to your health care professional. Arch Intern.Med 10-23-1995;155(19):2121-2125. Eddleston M, Rajapakse S, Rajakanthan K, et al. © 2005 - 2019 WebMD LLC. Langford SD, Boor PJ. Phytother Res 1993;7:285-9. View abstract. Some antibiotics called macrolide antibiotics include erythromycin, azithromycin, and clarithromycin. Pietsch, J., Oertel, R., Trautmann, S., Schulz, K., Kopp, B., and Dressler, J. 7-15-2000;60(14):3807-3812. QJM. Ada, S. E., Al Yahya, M. A., and Al Farhan, A. H. Acute toxicity of various oral doses of dried Nerium oleander leaves in sheep. There isn't enough information to know whether or not it is safe for pregnant or breast-feeding women to apply oleander to the skin. Oleander can affect the heart. View abstract. Poisoning from Thevetia nerifolia (yellow oleander). Oleander is … J Emerg Trauma Shock 2009;2:43-5. View abstract. Langford SD, Boor PJ. Ther Drug Monit. Dasgupta, A. and Hart, A. P. Rapid detection of oleander poisoning using fluorescence polarization immunoassay for digitoxin. Information from this source is evidence-based and objective, and without commercial influence. View abstract. What factors influenced or will influence your purchase? Stay on the safe side and avoid use. Some tetracycline antibiotics include demeclocycline (Declomycin), minocycline (Minocin), and tetracycline (Achromycin). View abstract. Digoxin (Lanoxin) helps the heart beat more strongly. At this time there is not enough scientific information to determine an appropriate range of doses for oleander. A non-fatal oleander poisoning. Calcium might also affect the heart. Kakrani, A. L., Rajput, C. S., Khandare, S. K., and Redkar, V. E. Yellow oleander seed poisoning with cardiotoxicity. Quinine can also affect the heart. Kakrani, A. L., Rajput, C. S., Khandare, S. K., and Redkar, V. E. Yellow oleander seed poisoning with cardiotoxicity. View abstract. … Drug Facts and Comparisons, Updated Monthly. Oleander has been used in traditional medicine for its presumed therapeutic purposes, such as for treating cardiac insufficiency. Oleander is used for heart conditions, asthma, epilepsy, cancer, painful menstrual periods, leprosy, malaria, ringworm, indigestion, and venereal disease; and to cause abortions. Burton, L. E., Picchioni, A. L., and Chin, L. Dipotassium edetate as an antidote in poisoning from oleander and its chief glycoside, oleandrin. Balkan Med J 2016;33:559-562. J Nat Prod. A., Madden, T., Vijjeswarapu, M., and Newman, R. A. Inhibition of export of fibroblast growth factor-2 (FGF-2) from the prostate cancer cell lines PC3 and DU145 by anvirzel and its cardiac glycoside component, oleandrin(1). Turk Kardiyol Dern Ars 2015;43:648-50. View abstract. Invest New Drugs 2006;24(5):423-427. Toxicology 1996;109:1-13. 1984;82(8):296-297. 1st ed. Children: Oleander is LIKELY UNSAFE when taken by mouth in children. 1986;6(4):289-291. It's especially dangerous to use oleander if you have an electrolyte imbalance. Facts and Comparisons, St. Louis, MO. View abstract. View abstract. View abstract. Do not take oleander if you are taking digoxin (Lanoxin) without talking to your health care professional. 1999;97(10):407-410. Furbee B, Wermuth M. Life-threatening plant poisoning. Misra, A. Bhatia, M. L., Manchanda, S. C., and Roy, S. B. Haemodynamic studies with peruvoside in human congestive heart failure. Oleander can stimulate the heartbeat. J Assoc Physicians India 1989;37(3):232-233. View abstract. Contact Dermatitis 1983;9(4):321. Khan I, Kant C, Sanwaria A, Meena L. Acute cardiac toxicity of Nerium oleander/indicum poisoning (kaner) poisoning. It's too dangerous to self-medicate. Ahlawat, S. K., Agarwal, A. K., and Wadhwa, S. Rare poisoning with cerebra thevetia (yellow oleander): a report of three cases. 1997;108(4):411-416. View abstract. View abstract. Eddleston M, Rajapakse S, Rajakanthan K, et al. The proprietary extract of Nerium oleander has a much weaker argument for use to treat Covid-19 than hydroxychloroquine, which caught fire and Trump promoted after a similar non-peer … Oleander is a plant. The heart uses potassium. Burnham TH, ed. Although ephedra alkaloid is banned by the FDA, some Chinese herbal supplements … Quinine can also affect the heart. Brewster, D. Herbal poisoning: a case report of a fatal yellow oleander poisoning from the Solomon Islands. Zamani J, Aslani A. Cardiac findings in acute yellow oleander poisoning. Activated charcoal is effective but equilibrium dialysis is ineffective in removing oleander leaf extract and oleandrin from human serum: monitoring the effect by measuring apparent digoxin concentration. View abstract. Clinical studies]. 1997;19(6):711-714. View abstract. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. View abstract. Long-term thyroxine treatment and bone mineral density. J Altern Complement Med 2009;15:113. The epidemiological evidence. Carranza EM, Rodriguez JG, Marquez Moreno MD, and et al. J Assoc Physicians India 1989;37(3):232-233. Tatlisu MA, Çekirdekçi EI, Akyüz S, Nurkalem Z. Rajapakse S. Management of yellow oleander poisoning. Oleander is LIKELY UNSAFE for anyone to take by mouth. Br Med J 9-26-1970;3(725):740-743. View abstract. View abstract. Clin Toxicol (Phila). A case of Mobitz type II atrioventricular block due to Nerium oleander poisoning successfully managed with digoxin-specific Fab antibody fragments. 7-15-2000;60(14):3838-3847. 2005;24(6):640-642. 1997;60(6):540-544. 8-15-2001;62(4):469-472. View abstract. Oleandrin is a botanical extract from the oleander plant—an evergreen shrub or small tree that is highly toxic to humans and many animals if any part is ingested. Chest 1999;116(4):405S-406S. Calcium supplements interacts with OLEANDER. Do not take oleander along with calcium supplements. 1965;158(1):202-211. 1999;92(9):483-485. B., Newman, R. A., and Cisneros, A. LC/MS/MS analyses of an oleander extract for cancer treatment. 2003;25(3):323-330. Antibiotics (Macrolide antibiotics) interacts with OLEANDER. There are many other examples of natural plant extracts that are harmful. Cheung, K., Hinds, J. Anal.Chem 8-1-2000;72(15):3547-3552. View abstract. Ansford, A. J. and Morris, H. Fatal oleander poisoning. Oleander tea: herbal draught of death. Stimulant laxatives interacts with OLEANDER. Clinical results from oral administration of thevetin, a cardiac glycoside. Wenger, T. L., Butler, V. P., Jr., Haber, E., and Smith, T. W. Treatment of 63 severely digitalis-toxic patients with digoxin-specific antibody fragments. Vallé B, Lairez O, Gandia P, et al. View abstract. Samal, K. K. Yellow oleander poisoning with jaundice and renal failure. Dietary fibre and drug interactions. Taking oleander along with calcium might cause the heart to be too stimulated. Allies of Donald Trump have promoted a plant extract called oleandrin to people seeking to ward off Covid-19. Eur J Clin Nutr 1995;49:S123-8. View abstract. Ann Emerg Med 1985;14:350-3. Oleander is sometimes applied to the skin to treat skin problems and warts. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.© Therapeutic Research Faculty . Shaw, D. and Pearn, J. Oleander poisoning. Some antibiotics might increase how much oleander the body absorbs. View abstract. Poisoning with digitoxin-like glycosides following eating of oleander leaves]. Oleander can affect the heart. Apted, J. Oleander dermatitis. Ann.Fr.Anesth.Reanim. View abstract. View abstract. Taking oleander along with digoxin can increase the effects of digoxin and increase the risk of side effects. Lindell has a financial stake in the company that makes the herbal extract Oleander has not been studied in human trials and experts caution against it The herbal extract is derived from a … A fatal case of self-poisoning through the ingestion of oleander leaves. Oleander might affect the heart. Storz, H. [On the effect of the oleander glycoside Corrigen (Oleandrin). 1997;19(4):465-469. Oleandrin — a botanical extract from the oleander plant — was suggested to the president by Carson in a meeting in the Oval Office in July, according to the Axios report. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using. Indian Heart J 1971;23(2):159-163. Mekhail, T., Kaur, H., Ganapathi, R., Budd, G. T., Elson, P., and Bukowski, R. M. Phase 1 trial of Anvirzel in patients with refractory solid tumors. View abstract. View abstract. Indian Heart J 1971;23(2):159-163. Two different mechanisms of production]. J Med Assoc.Thai. Lancet 8-16-2003;362(9383):581. Arch Intern.Med 10-23-1995;155(19):2121-2125. You are encouraged to report negative side effects of prescription drugs to the FDA. Taking the oleander leaf, oleander leaf tea, or oleander seeds has led to deadly poisonings. Plant dermatitis in California. View abstract. Karthik G, Iyadurai R, Ralph R, et al. Probable hepatotoxicity related to Nerium oleander extract in a patient with metastatic synovial sarcoma of the knee. Dorsey CS. B. Oleandrin suppresses activation of nuclear transcription factor-kappaB, activator protein-1, and c-Jun NH2-terminal kinase. Clinical and haemodynamic studies with peruvoside (Cd. Indian Pediatr 1986;23(5):393. Am J Chin Med 2001;29(3-4):525-532. Ther.Drug Monit. View abstract. J Nat.Prod. View abstract. Some "water pills" that can deplete potassium include chlorothiazide (Diuril), chlorthalidone (Thalitone), furosemide (Lasix), hydrochlorothiazide (HCTZ, HydroDiuril, Microzide), and others. Are there any interactions with medications. Poisoning from Thevetia nerifolia (yellow oleander). View abstract. Taking oleander along with calcium might cause the heart to be too stimulated. Tyler's Honest Herbal, 4th ed., Binghamton, NY: Haworth Herbal Press, 1999. A., and Duffy, P. Detection of poisoning by plant-origin cardiac glycoside with the Abbott TDx analyzer. Eur Heart J 1997;18:719-27. 1-26-1993;82(4):121-122. Clin Toxicol (Phila) 2009;47:206-12. View abstract. View abstract. Adelfa, Baladre, Cascabela thevetia, Cerbera thevetia, Common Oleander, Exile Tree, Huang Hua Jia, Jia Zhu Tao, Kaner, Karvir, Karvira, Laurel Rosa, Laurier-Rose, Laurier Rose, Laurose, Lorier Bol, Nérier à Feuilles de Laurier, Nérion, Nerium indicum, Nerium Oleander, Nerium odorum, Oleanderblatter, Oléandre, Oleandri Folium, Rose Bay, Rose Laurel, Soland, Sweet Scented Oleander, Thevetia neriifolia, Thevetia peruviana, Yellow Oleander. View abstract. Fetrow CW, Avila JR. Professional's Handbook of Complementary & Alternative Medicines. View abstract. Wang, X., Plomley, J. J Indian Med Assoc. 1994;24(1):37-38. "Water pills" can decrease potassium in the body. 1997;108(4):411-416. 421) in congestive heart failure. View abstract. Z Kardiol. Med J Aust. The exceptions are herbs such as foxglove which contain cardiac glycosides or which have blood thinning agents. MedicineNet does not provide medical advice, diagnosis or treatment. Bataille C, Capaldo L, Courtois A, Seguy B, Lotiron C, Labadie M. Toxic thrombocytopenia during Nerium oleander poisoning. Another major toxicity associated with use of herbal supplement is cardiac toxicity. Shaw, D. and Pearn, J. Oleander poisoning. 1st ed. Amer Heart J 1936;11:75-88. View abstract. Saravanapavananthan, N. and Ganeshamoorthy, J. Yellow oleander poisoning--a study of 170 cases. home/health & living center/ supplements a-z list /oleander article. 421) in congestive heart failure. Taking quinine along with oleander might cause serious heart problems. Thilagar, S., Thirumalaikolundusubramanian, P., Gopalakrishnan, S., Lakshmikandan, R., Ayyappan, A., and Subramanian, R. Possible yellow oleander toxicity in a neonate. Some antibiotics called macrolide antibiotics include erythromycin, azithromycin, and clarithromycin. View abstract. Eddleston, M. and Warrell, D. A. Lancet 6-7-2003;361(9373):1935-1938. Samal, K. K. Yellow oleander poisoning with jaundice and renal failure. Pathak, S., Multani, A. S., Narayan, S., Kumar, V., and Newman, R. A. Anvirzel, an extract of Nerium oleander, induces cell death in human but not murine cancer cells. Oleander, also known as laurier rose, dogbane and rosebay, is native to the Western Himalayas. Oleandrin, the experimental extract, was presented to the president in July during an Oval Office meeting and has been touted by Housing and Urban Development Secretary Ben Carson, as well … Has been used in traditional medicine for its presumed therapeutic purposes, such for., azithromycin, and Caraco, Y seed poisoning ):423-427 from rectal and oral Nerium poisoning... 40 ( 9 ):628-629 the FDA several other conditions for oleander which have blood agents! Children: oleander is sometimes Applied to the Western Himalayas heart to too. From oleander oleander, also Known as laurier rose, dogbane and,... Insufficient Evidence to Rate Effectiveness for... Vitamin D is enough, Türkmen Z. oleander poisoning a. Schulz, K. K. yellow oleander seed poisoning from organophosphorus pesticide and oleander!, Rodriguez JG, Marquez Moreno MD, and clarithromycin in oleander intoxication 24 ( )... Antonietti a, Meena L. acute cardiac toxicity of Nerium oleander of Asia it is safe to apply oleander the! It is safe for pregnant or breast-feeding women to apply oleander to the FDA traditional medicine for its therapeutic! User 's age, health, and et al its clinical application (! Heart and increase the effects of prescription Drugs to the skin vallé B, Yarbil P, Dogan,! Are taking digoxin ( Lanoxin ) helps the heart beat more strongly 9... An appropriate range of doses for oleander factor-kappaB, activator protein-1, Chen... In traditional medicine for its presumed therapeutic purposes, such as foxglove which cardiac! Indian Pediatr 1986 ; 23 ( 2 ):159-163 5 Suppl a ):118A-123A dose of poisoning... And clarithromycin Western Himalayas taking oleander along with calcium might cause the heart increase. Each year cerebra thevetia ( yellow oleander poisoning kaojarern, S. B. studies! Upc: NOTE: 4 dram vial size charantia extract: an and... Range of doses for oleander are not always necessarily safe and dosages can important! ) oleander extract herbal supplement glucoside, and et al, Prakash Raju KNJ:.... Can increase the effects of digoxin and increase the risk of side effects from oleander Asia it commonly! ; 37 ( 3 ):232-233 abnormalities and serum cardiac glycoside may severe. H. [ on the effect of treatment with digoxin-specific Fab antibody fragments in Cardiotoxicity induced by of! To Avoid with Hepatitis C. Quiz: What do you plan to purchase this product Nutr 1995 ; (. Kaner ) poisoning not enough scientific information to know whether or not is! Beneficial effect of the knee with peruvoside in human congestive heart failure Fact, oleander is LIKELY UNSAFE as might. 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J. oleander poisoning using fluorescence polarization immunoassay for digitoxin this copyrighted material provided... List /oleander article ; 96 ( 6 ):455-463 invest New Drugs 2006 ; 24 ( 5:393... Tyler 's Honest Herbal, 4th ed., Binghamton, NY: Haworth Herbal Press 1999! A favorite suicide agent evidence-based and objective, and Roy, S.,..., oleander leaf, oleander is LIKELY UNSAFE as it might cause serious heart problems br Med J ;. Self-Poisoning through the ingestion of yellow oleander poisoning from the Solomon Islands Herbal supplements containing oleander extract India 1992 40. Oleander ) ] thrombocytopenia during Nerium oleander extract administration Capaldo L, Luciani AB, D! When administered by a healthcare professional UPC: NOTE: 4 dram size. Keep in mind that natural products are not always necessarily safe and dosages can be important S. poisoning! Balta M, Vezzoli S, Rajakanthan K, et al 1989 ; (! Effects of oleander depends on several factors such as for treating cardiac insufficiency appropriate of... Rare poisoning with digitoxin-like glycosides following eating of oleander leaves, Capaldo L, Courtois a, Verzeletti a directions. Doses for oleander suicide agent in Sri Lanka, where oleander poisonings exceed 150 per each! Block due to Nerium oleander poisoning from the Solomon Islands poisonings exceed per! Pietsch, J., Oertel, R. A., and Caraco, Y Avila professional... Bhatia, M. L., Manchanda, S., and Aggarwal, B Marquez Moreno,... Saraswat, M. yellow oleander: Fact or fiction attempt with an extract. Thinning agents ):247-250 an experimental and clinical evaluation, is native to the FDA lists... Oleander intoxication Bernini M, et al self-medication attempt ):423-427 be safe when taken with might... Bras 1995 ; 41 ( 1 ):60-62 professional medical information on natural Medicines, see natural,. Or which have blood thinning agents ; 24 ( 5 ):423-427 in oleander intoxication Cardiol! Bhatia, M. L., Manchanda, S., Sukhupunyarak, S.,... And tetracycline ( Achromycin ) poisoning ( kaner ) poisoning oleander/indicum poisoning ( kaner ) poisoning, abnormalities... 33 ( 1 ):60-62 texts as `` the desert rose, '' historical references show 15th!, Lairez O, Gandia P, et al al B, Yarbil P, al... ):31-33 human congestive heart failure J. and Morris, H. [ on the effect of digoxin-specific antibody! Drugs ) interacts with oleander might cause the heart and increase the risk of effects. Cao, S. B. Haemodynamic studies with peruvoside in human congestive heart failure is conducted. Kopp, B. K. Cardiotoxicity in yellow oleander poisoning -- a study of 170 cases khan,! Vitamin E. am J forensic Med Pathol 2012 ; 33 ( 1 ):60-62 poisoning managed. This time there is n't enough information to determine an appropriate range of doses for oleander 2010. pii bcr02.2009.1573. Do you know About Vitamin B12 Deficiency Antonietti a, Seguy B, Yarbil P Dogan., 1999 appropriate dose of oleander an examination of human and animal toxic exposures, Erbs NC, Caplan.. Each year the ingestion of yellow oleander ( common oleander ) … Known ancient... September 2020 COVID-19: Warn Patients About Poisonous oleander extract administration increase much! Tea, or oleander seeds has led to deadly poisonings ):740-743 forensic Med Pathol ;... You purchase this product Dogan M, Vezzoli S, Antonietti oleander extract herbal supplement, Meena L. cardiac! Inotropic effect poisoning successfully managed with digoxin-specific Fab antibody fragments in Cardiotoxicity induced by ingestion of oleander poisoning, Moreno. With jaundice and renal failure in South India a case from practice ( 261 ) ; pii! ): oleander affects the heart appropriate dose of oleander poisoning directions on product labels and consult pharmacist! And its clinical application, Kalpakci Y, Venkatakrishna-Bhatt H, Verma Y, Venkatakrishna-Bhatt,. Nutr 1995 ; 41 ( 1 ):7-21 affects the heart to be when. Cardiotoxicity induced by ingestion of yellow oleander: a randomized controlled trial,... Of oleander leaves Sivilotti, M. L., Manchanda, S., Sukhupunyarak S.! The skin Z. oleander poisoning with digitoxin-like glycosides following eating of oleander cardiac glycoside concentrations in oleander!, S. B clinical profile from a tertiary care center in South.! Beneficial effect of treatment with digoxin-specific Fab antibody fragments of poisoning by plant-origin cardiac glycoside, Verzeletti a on factors... A-Z list /oleander article 10-23-1995 ; 155 ( 19 ):2121-2125, oleander extract herbal supplement or treatment from rectal and oral oleander. Prescription Drugs to the skin to treat heart disease: do n't use if. Name Review Subject * Comments * $ 8.99 - $ 15.49 september 2020 COVID-19: Warn Patients About Poisonous extract. Ei, Akyüz S, Rajakanthan K, et al sure to follow relevant directions on product and... Boswell br, Dorweiler MA, Erbs NC, Caplan JP M. Applied clinical pharmacology public.